The Buffalo Bills‘ defense has quickly cemented itself as one of the very best in the NFL. The league’s best safety duo and a great pass-rushing unit that doesn’t require a fifth man to get to the quarterback.

Such a unit will be put to the best when the Miami Dolphins host the Bills on Sunday. Unfortunately, the Bills’ defense will be missing at least three key starters on defense.

On Friday, head coach Sean McDermott confirmed on live radio the following players have been ruled out:

  • DT Jordan Phillips
  • CB Dane Jackson
  • S Micah Hyde

On top of that, Jordan Poyer is day-to-day and is part of a group of players that the Bills want to “wait and see” ahead of gameday.

“I’m very confident in our football team,” said McDermott in Friday’s press conference. “I know we have a number of injuries, but I’m very confident in our team and our back end in particular.”

This latest cluster of injuries put the Bills’ rookie cornerbacks in a tough position. Kaiir Elam and Christian Benford will find themselves matching up against Hill and Waddle duo that combined for 361 receiving yards last weekend.

The Bills’ defense has been able to generate pressure, look solid in coverage, and stop the run from the same defensive personnel grouping. They’ve played nickel at one of the highest rates in the league and can do everything from that package.

Whether or not Leslie Frazer adapts his approach with lesser talent will be one the biggest storylines heading into Sunday.