The Philadelphia Eagles take on the San Francisco 49ers for a chance to reach the Super Bowl.

Going into the matchup, the Eagles are a 2.5-point favorite at home. A virtual pick em. With the latest inactive's for the game today, the line may have moved more in Philadelphia's favor.

With the 49ers being without one of their key play-making running backs.

Philadelphia Eagles Inactives:

• QB Ian Books
• DB Josiah Scott
• RB Trey Sermon
• DB Anthony Harris
• LB Kyron Johnson
• OL Josh Sills

San Francisco 49ers Inactives:

• QB Jimmy Garoppolo
• RB Tyrion Davis-Price
• OL Nick Zakelj
• TE Ross Dwelley
• RB Elijah Mitchell
• DL Drake Jackson
• DB Ambry Thomas

RB Elijah Mitchell has missed extended time twice this season already and will be gone for the NFC Championship as well.

Considering the 49ers rushing attack is predicated on the uses of both Mitchell and Christian McCaffrey. With added power from WR Deebo Samuel. However, an extended use of Samuel as a running back is not what the 49ers want.

The Eagles defense has been susceptible to the run, giving up 4.6 yards per carry. The absence of one of their key cogs being out helps the Eagles chances.

Mandatory Credit: Kirby Lee of USA TODAY Sports