It's no surprise, but Vegas' continued faith in the San Francisco 49ers has only been strengthened by their Week 10 demolition of the Jacksonville Jaguars.

The favorite in every game they have played this season, the Niners backed up their status as road favorites against the Jaguars by surging to a 34-3 win, which ended a three-game losing streak.

Following that triumph, the 49ers return to Levi's Stadium to face the Tampa Bay Buccaneers, who are coming off a 20-6 win over the Tennessee Titans that improved their record to 4-5.

But the bookmakers see little chance of Tampa Bay upsetting the Niners, whom they designated as 10.5-point favorites, per betonline.ag.

The 49ers have won their last two meetings with the Buccaneers, prevailing on the road in 2019 before cruising to a 35-7 victory at Levi's Stadium in Brock Purdy's first start last season.

Purdy will be widely expected to create more fond memories of playing the Bucs, having defeated Tom Brady in a remarkable showing last December.

The over/under for the game is set at 42.

49ers have huge opportunity in NFC playoff picture after Week 10 win

They’re in an intriguing spot.