The San Francisco 49ers face a tricky road test in Week 6 against the Cleveland Browns, one that will put their status of 'best team in football' under significant examination.

San Francisco won't be facing Browns quarterback Deshaun Watson, who is out with a rotator cuff injury. That news has swelled the point spread, with the Niners now 10-point favorites to move to 6-0.

But the Browns defense is unlikely to make things straightforward for Brock Purdy and the offense. Cleveland's defense is ranked first in DVOA, per FTN Fantasy and boasts a deep and dynamic front led by edge rusher Myles Garrett.

Purdy shredded a much-vaunted defense in front of national audience last week as the 49ers crushed the Dallas Cowboys 42-10, and most of the country will get to see him attempt to do the same in Cleveland.

Will you have the opportunity to watch on TV? If you live in any of the red areas on the below map, you will be able to watch the game on Fox during the 1 p.m. ET slot.

The parts of the country not listed in the read areas will watch the Minnesota Vikings at the Chicago Bears or the New Orleans Saints at the Houston Texans.

For the first time this season, the 49ers will have their game called by Fox's number one broadcast team, Kevin Burkhardt and Greg Olsen, with Erin Andrews and Tom Rinaldi as the sideline reporters.

Second 49ers injury report for Week 6, at Browns

A new injury worry for the 49ers.