The San Francisco 49ers made it official that Dre Greenlaw will make his long-awaited return from a torn Achilles against the Los Angeles Rams, and the signs are that Nick Bosa will also be available for must-win primetime game. 

San Francisco confirmed hours before kickoff that linebacker Greenlaw, who suffered his devastating injury running onto the field in the second quarter of Super Bowl 58, had been activated from the PUP list to the 53-man roster. He takes the place of guard Ben Bartch, who has been placed on injured reserve. 

Star defensive end Bosa, meanwhile, was on Wednesday listed as questionable with the hip/oblique injuries that have seen him miss the last three games. 

But ESPN's Adam Schefter reported the 2022 Defensive Player of the Year is likely to make his return, though Bosa will test his injuries out pregame before a final decision is made. 

With the 49ers set to face a Rams offense that was red hot in Los Angeles' thrilling win over the Buffalo Bills last week, the emotional lift from Greenlaw's return and the pass-rushing prowess of Bosa could be huge in allowing San Francisco to slow down Matthew Stafford and Co.

On the offensive side of the ball, the 49ers made an additional move, elevating running back Ke'Shawn Vaughn from the practice squad.

Vaughn provides extra depth in the backfield with rookie starter Isaac Guerendo battling a foot sprain. Guerendo is expected to play. Israel Abanikanda, claimed off waivers last week after Christian McCaffrey and Jordan Mason suffered season-ending injuries, appears likely to once again be inactive as he acclimates to the offense.

49ers receive incredible emotional boost hours before kickoff of must-win game against Rams

It could be a crucial emotional lift.