George Kittle’s next game for the 49ers may be weeks away following a concerning injury update out of San Francisco

The injuries aren’t going away in the Bay.

Rob Gregson — NFL News Writer
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Sep 7, 2025; Seattle, Washington, USA; San Francisco 49ers tight end George Kittle (85) celebrates after scoring a touchdown during the first half against the Seattle Seahawks during the first quarter at Lumen Field.
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At this point, if San Francisco 49ers fans see Kyle Shanahan approaching a microphone, they should probably just turn away. It feels like every time he speaks, the team is hit with a new injury. That was no different on Monday, when the head coach announced that Brock Purdy is dealing with multiple ailments, and that George Kittle’s hamstring injury might be worse than initially thought.

Shanahan said that Kittle will be sidelined for a few weeks with the hamstring injury, but according to Ian Rapoport of NFL Media, it could be over a month until Kittle is back on the field, making him a candidate for short-term injured reserve.

George Kittle is expected to miss 3-5 weeks, could land on injured reserve

If you go through the 49ers’ offensive skill groupings and the quarterback position, I’m not sure you can find a time this offseason when all of their players were healthy. Brandon Aiyuk has been out since last year, Christian McCaffrey had an injury scare last week.

Now Purdy may give way to Mac Jones as the starter, and the team will be without their best TE, and arguably their best offensive weapon. Kittle looked dominant before he went down with the hamstring against the Seattle Seahawks. The game had just started and he recorded four receptions. And now he could be out four weeks.

At some point, the 49ers have to take a long look in the mirror. This is starting to become a Los Angeles Chargers from the 2010s situation, where every offseason and season they were hit with multiple soft tissue and ligament injuries.

Purdy is a little different given it’s a toe and a shoulder, but calves, hamstrings, ACLs, they have all hampered key starters in San Francisco. I’m not sure that’s just a coincidence at this point.

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