The Week 12 NFL slate kicks off with the Cleveland Browns hosting the Pittsburgh Steelers.

The Steelers are looking to hold on to their AFC North lead and stay in contention for the No. 1 seed in the conference, while the Browns look to finish a disappointing season with some positivity and momentum.

Here are our best prop bets for tonight's game.

*Odds subject to change

Steelers RB Najee Harris OVER 64.5 rushing yards (-114) – FanDuel

Harris is the workhorse of the Steelers' offense, averaging 20 rushing attempts over his last four games and 88 rushing yards over his last five.

Getting Harris going is a point of emphasis for Pittsburgh's offense so that quarterback Russell Wilson can push the ball down the field off of play-action. Harris has eclipsed 64 rushing yards six times this season, and the Browns rank 24th in run defense, allowing an average of 132 yards per game.

Browns WR Jerry Jeudy OVER 43.5 receiving yards (-120) – DraftKings

After a slow start to the season, Jeudy has been integrated within the Browns' offense in a big way over the past month. Jeudy has averaged 98 receiving yards during his last three games, and last week against the New Orleans Saints he caught six passes for a season high 142 yards and a touchdown.

Jeudy has established a great chemistry with quarterback Jameis Winston and has provided Cleveland's offense with a much needed deep threat. The Steelers have great overall defense, but have actually been middling against the pass.

Steelers QB Russell Wilson OVER 0.5 passing touchdowns (+190) – DraftKings

Wilson was held without a touchdown pass against the Baltimore Ravens in a defensive struggle last week, but as we know, that's just how Steelers-Ravens matchups go.

Before that game, Wilson averaged two touchdown passes per game since taking over as the starting quarterback. Pittsburgh should be able to run the ball efficiently against a subpar Browns' rush defense, which should open up opportunities for Wilson in the passing game.

Browns RB Nick Chubb UNDER 53.5 rushing yards (-115) – BetMGM

Chubb hasn't quite rounded back into form since returning from his devastating left knee injury that he suffered in 2023. He is averaging just 3.1 yards per carry and hasn't gone over 53 rushing yards in any of his four games this season. 

This week Chubb faces a daunting matchup against a Steelers defense that ranks fourth in the NFL against the run. Winston is averaging a whopping 44 passing attempts per game since taking over as the starting quarterback, limiting the number of carries for Chubb.