The Detroit Lions travel to Indianapolis to take on the Colts in Week 12.

Check out our full odds, picks and predictions for this matchup. Now, here are our best prop bets for Lions vs. Colts.

*Odds subject to change

Lions WR Amon-Ra St. Brown ANYTIME touchdown (-125) – Caesars Sportsbook

This is one of the most surefire bets that can be made. St. Brown has caught at least one touchdown pass in eight straight games. His nine total are good for the second most in the NFL.

He’s coming off a season high 161 yards and two touchdowns against the Jacksonville Jaguars last week, and this week he faces an Indianapolis Colts defense that ranks 26th against the pass.

Colts QB Anthony Richardson OVER 202.5 passing yards (-117) – Caesars Sportsbook

Richardson made a bigtime return to the starting lineup last week, throwing for 272 yards and a touchdown, and adding two rushing touchdowns. Richardson seems rejuvenated since being benched a few weeks ago, and he'll need to keep up with the explosive Lions' offense.

He could be bottled up a bit as a runner since Detroit ranks fifth in rushing defense, but it ranks ranks 27th against the pass. In a game that could turn into a shootout and is being played in a dome, this is a good bet.

Lions RB David Montgomery ANYTIME touchdown (-175) – Caesars Sportsbook

Montgomery is having another stellar season for Detroit, ranking second in the NFL in rushing touchdowns with 10. He is the Knuckles to fellow running back Jahmyr Gibbs' Sonic, meaning when the Lions get close to the goal line, Montgomery is getting the ball.

Montgomery has found the endzone in every game but two this season, and four times in his last four games. He also has a great matchup against a Colts defense that ranks 28th against the run.

Colts RB Jonathan Taylor UNDER 70.5 rushing yards (-110) – bet365

As mentioned above, the Lions have a very good run defense. Taylor has been held under 70 rushing yards in two of his last three games, and he'll surrender a handful of rushing attempts now that Richardson is back at quarterback.

The Colts are going to have to hang with Detroit on the scoreboard, so staying committed to the running game will be difficult.