With NFL Week 1 on the horizon, the ways to enjoy the games have hit an all-time high. Whether it’s simply backing your favorite team, rooting for your fantasy players or trying to find value in an abundance of betting markets, the ways to approach each matchup are virtually endless.

Our experts are here to help with that by sticking with a tried and true market – the spread. So, we have their best NFL Week 1 picks against the spread below paired with a two-part FanDuel Sportsbook promotion with a guaranteed value of $300.

NFL WEEK 1 PICK AGAINST THE SPREAD: Las Vegas Raiders +4 (-110 at FanDuel Sportsbook)

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NFL Week 1 Picks Against The Spread at FanDuel Sportsbook

When we said we have NFL Week 1 picks against the spread for all 16 games, we weren’t exaggerating, and our NFL Week 1 predictions are bolded for you below:

Thursday, September 7:

• Detroit Lions +6.5 vs. Kansas City Chiefs -6.5

Sunday, September 10:

• Jacksonville Jaguars -4.5 vs. Indianapolis Colts +4.5
• Houston Texans +10 vs. Baltimore Ravens -10
• San Francisco 49ers -2.5 vs. Pittsburgh Steelers +2.5
• Tampa Bay Buccaneers +6 vs. Minnesota Vikings -6
• Tennessee Titans +3 vs. New Orleans Saints -3
• Arizona Cardinals +7 vs. Washington Commanders -7
• Cincinnati Bengals -2.5 vs. Cleveland Browns +2.5
• Carolina Panthers +3.5 vs. Atlanta Falcons -3.5
• Philadelphia Eagles -3.5 vs. New England Patriots +3.5
• Green Bay Packers +1.5 vs. Chicago Bears -1.5
• Los Angeles Rams +5.5 vs. Seattle Seahawks -5.5
• Las Vegas Raiders +4 vs. Denver Broncos -4
• Miami Dolphins +3 vs. Los Angeles Chargers -3
• Dallas Cowboys -3.5 vs. New York Giants +3.5

Monday, September 11:

• Buffalo Bills -2.5 vs. New York Jets +2.5

NFL Week 11 Predictions Featuring Las Vegas Raiders vs. Denver Broncos

Out of all our NFL Week 1 picks against the spread above, our favorite is the Sunday afternoon matchup between AFC West division rivals – the Las Vegas Raiders and Denver Broncos. Both teams disappointed last season, but perhaps none more so than the Broncos.

It has been discussed a great amount, but it doesn’t make it any less true. Former Seattle Seahawks QB Russell Wilson was a shell of his former self. Of course, the offseason discussions have been all about how Denver brought in head coach Sean Payton to revitalize his career.

We’ll believe it when we see it. It also doesn’t help their case that throughout training camp and the preseason, the Broncos lost a significant portion of their receiving corps. That includes WR Jerry Jeudy and Tim Patrick, and TE Noah Fant is no longer on the team. As for the Raiders, they have arguably the best WR in the game – Davante Adams.

It also isn’t as if the Broncos have only recently struggled against the Raiders. Denver is 2-8 against Las Vegas in their last 10 meetings, and it’s even worse against the spread. They’re 1-9 in that regard, in what have primarily been low-scoring affairs. Those type of contests generally favor the underdog, which is just another reason why the Raiders +4 (-110 at FanDuel Sportsbook) is the best bet from our NFL Week 1 picks against the spread.

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NFL Week 1 Schedule & Betting Lines Provided by FanDuel Sportsbook, September 2023

We shared our NFL Week 1 picks against the spread for all 16 games above, and now you can see them with the latest odds at FanDuel Sportsbook. For our best bet on the Raiders +4, that has -110 odds, so an $11 wager profits $10 as long as they lose by three or fewer points or pull off the outright upset.

Thursday, September 7:

• Detroit Lions +6.5 (-105) vs. Kansas City Chiefs -6.5 (-115)

Sunday, September 10:

• Jacksonville Jaguars -4.5 (-114) vs. Indianapolis Colts +4.5 (-106)
• Houston Texans +10 (-110) vs. Baltimore Ravens -10 (-110)
• San Francisco 49ers -2.5 (-110) vs. Pittsburgh Steelers +2.5 (-110)
• Tampa Bay Buccaneers +6 (-110) vs. Minnesota Vikings -6 (-110)
• Tennessee Titans +3 (-105) vs. New Orleans Saints -3 (-115)
• Arizona Cardinals +7 (-105) vs. Washington Commanders -7 (-115)
• Cincinnati Bengals -2.5 (-110) vs. Cleveland Browns +2.5 (-110)
• Carolina Panthers +3.5 (-110) vs. Atlanta Falcons -3.5 (-110)
• Philadelphia Eagles -3.5 (-115) vs. New England Patriots +3.5 (-105)
• Green Bay Packers +1.5 (-118) vs. Chicago Bears -1.5 (-104)
• Los Angeles Rams +5.5 (-106) vs. Seattle Seahawks -5.5 (-114)
• Las Vegas Raiders +4 (-110) vs. Denver Broncos -4 (-110)
• Miami Dolphins +3 (-110) vs. Los Angeles Chargers -3 (-110)
• Dallas Cowboys -3.5 (-105) vs. New York Giants +3.5 (-115)

Monday, September 11:

• Buffalo Bills -2.5 (-110) vs. New York Jets +2.5 (-110)

Enjoy adding excitement to each and every game and lock in your NFL Week 1 predictions by joining FanDuel today for your double-gifted promotion.

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