The Buffalo Bills host the Kansas City Chiefs for AFC supremacy in Week 11.

Check out our full odds, picks and predictions for this matchup. Now, here are our best prop bets for Bills vs. Chiefs.

*Odds subject to change

Bills QB Josh Allen OVER 230.5 passing yards (-115) – DraftKings

Allen has thrown for over 230 yards in each of his last four games, and in every home game this season. The Chiefs have a middling pass defense, and their secondary hasn't been the same since underrated cornerback Jaylen Watson went down with an injury. 

The main focus for Kansas City's defense is usually stopping the run, which opens things up for offenses in the passing game. The Chiefs are often vulnerable in the middle of the field. Allen has had some of the best performances of his career against K.C., even in losing efforts.

Chiefs WR DeAndre Hopkins OVER 50.5 receiving yards (-117) – Caesars Sportsbook

Hopkins is a natural fit for the Chiefs' offense and is already by far the best wide receiver on the roster. He still has plenty of juice left at 32-years-old and is a master route runner. Hopkins has eclipsed 50 receiving yards in each of his last two games.

The Bills' defense ranks in the middle of the pack of the league in receiving yards allowed. With that matchup and the volume he should get, Hopkins should have no problem getting over 50 yards.

Bills TE Dawson Knox ANYTIME touchdown (+260) – DraftKings

It appears that Bills starting tight end Dalton Kincaid won't play in this game. Six-year veteran Knox will be the next man up. He knows the Bills' offense well and produced solid numbers as a starter before Buffalo drafted Kincaid last year.

The Chiefs have been horrible against tight ends this season, allowing the third-most receptions, most yards and fourth-most touchdowns to the position. Knox is an excellent redzone target and 6-foot-4 and 254 pounds, and has 23 career touchdowns.

Chiefs TE Travis Kelce OVER 6.5 receptions (-125) – Caesars Sportsbook

Early speculation of Kelce’s demise were greatly exaggerated. He has caught more than six passes in five of his last six games, and set a career high in receptions in a single game two weeks ago with 14.

Kelce leads all tight ends in catches this season with 60, and ranks third in receiving yards with 499. He is still quarterback Patrick Mahomes’ go-to target and is the most important piece of the Chiefs’ passing game. In two games against the Bills last year Kelce caught 11 passes.