While Josh Allen and the Buffalo Bills have yet to get over the hump in the AFC that is the Kansas City Chiefs (or Denver Broncos in 2025), one thing that we know is when those two teams face off, it’s going to be a spectacle.

And while we don’t know the entirety of the Bills’ 2026 schedule, bits and pieces are starting to leak out, and one of the games that is confirmed is another huge matchup with the Chiefs.

Bills-Chiefs to play one of the biggest games in 2026

“This one is easy, and it’s been a relatively frequent matchup in the AFC. Don’t be surprised if the NFL schedules this game for late in the season, so they can secure the full Patrick Mahomes-Josh Allen experience. Mahomes is recovering from an ACL injury.”

“Since Mahomes and Allen became NFL starters in 2018, these two rivals have faced off 10 times, with five wins for each side. However, Kansas City won all four playoff games. At least for this specific game, there’s a positive side for the Bills, who’ve won most of their regular-season head-to-heads this decade.” – Wendell Ferreira, A to Z Sports

Will Patrick Mahomes play?

While every Bills fan will be looking for a win when these two teams face off, let’s be honest, it’s not the same without Patrick Mahomes in the mix. He released a video of himself taking drops a while back, and it is believed that he will participate in OTAs when they begin in Kansas City.

However, his readiness for the 2026 season remains up in the air. If Bills-Chiefs is scheduled for early in the year, then it would be tough to envision Mahomes playing, but post-Halloween or just in time for the Holiday season makes a ton of sense from a viewing perspective.