The San Francisco 49ers are 0-5 in games in which Nick Bosa and Trent Williams do not play.

After heavy defeats to the Green Bay Packers and Buffalo Bills without the All-Pro pair, there is a small chance the 49ers could get one of them back on Sunday against the Chicago Bears. 

While left tackle Williams has been ruled out for a third straight game, the 49ers have listed Bosa as doubtful, despite the defensive end once again missing an entire week of practice.

Head coach Kyle Shanahan said Bosa was able to do a little bit more this week, but Williams will once again be a spectator as Jaylon Moore continues to hold the fort at left tackle.

Left guard Aaron Banks is listed as questionable as he remains in concussion protocol, but defensive tackle Jordan Elliott is off the injury report with the same issue. Ben Bartch is likely to again deputize for Banks if he cannot go, Bartch having impressed in the loss to Buffalo.

Safety Talanoa Hufanga (wrist) is also questionable, leaving open the possibility of him being activated from injured reserve. However, linebacker Dre Greenlaw will not be activated to the 53-man group this week, with his long-awaited return from his Super Bowl Achilles injury more likely to come next Thursday against the Los Angeles Rams.

Safety George Odum will miss out with a knee injury that popped up on Thursday, but cornerback Deommodore Lenoir will return from a knee injury that kept him out of the Bills game. 

Defensive end Yetur Gross-Matos has also shaken off a knee issue and is off the injury report.

49ers injury report

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They’re in the last chance saloon.