The San Francisco 49ers desperately need a win over the Green Bay Packers to revive their ailing playoff hopes, and their chances of achieving that feat just got substantially harder.

Head coach Kyle Shanahan confirmed on Friday that starting quarterback Brock Purdy is out of Sunday's game at Lambeau Field, having missed Friday's practice following limited involvement on Wednesday and Thursday because of shoulder soreness.

The game with the Packers may not be the only one Purdy misses, with head coach Kyle Shanahan describing his signal-caller as "up in the air" for the Week 13 matchup with the Buffalo Bills in primetime.

On top of that, the 49ers will also be without defensive end Nick Bosa because of injuries to both of the 2022 Defensive Player of the Year's hips/obliques.

One positive is that All-Pro left tackle Trent Williams still has a chance to play. Williams is considered questionable with the ankle injury he fought through in last week's surprise loss to the Seattle Seahawks.

Shanahan said Williams will be given "right up until kickoff".

Cornerback Charvarius Ward will be out despite returning to practice this week. Ward had missed the last two games following the death of his one-year old daughter.

Rookie wide receiver Jacob Cowing has not cleared the concussion protocol and will miss out along with defensive tackle Kevin Givens, whose groin issue will once again keep him on the sideline.

Veteran offensive lineman Jon Feliciano (knee) looks to finally have a chance to be activated from injured reserve and make his season debut. Feliciano is listed as questionable.

49ers injury report

Brock Purdy gives massive clue to his status for 49ers’ critical Week 12 matchup with Packers

It’s not looking good.