Monday Night Football has been a staple in the NFL for decades. This year is getting started with a bang as Super Bowl contenders clash when the Buffalo Bills face the New York Jets. If you’re looking for great Monday Night Football picks against the spread, our team has you covered.

Read on to find all of the best Monday Night Football picks against the spread, including picks against the spread. We’ll cover the odds, the injury report, how you can win $200 no matter what the pick is, and provide you with the best Monday Night Football picks against the spread with odds provided by DraftKings for Week 1 of the NFL.

BUFFALO BILLS VS. NEW YORK JETS: Buffalo Bills -2.5 (-110 at DraftKings Sportsbook)

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Monday Night Football Picks Against the Spread for Bills vs. Jets on Monday, 9/11

So, what are our best Monday Night Football picks against the spread? Though all the hype is currently on the Jets – who were also the stars of HBO’s Hard Knocks – no one should forget about the Bills. They are still the best team in the AFC East and that shouldn’t change this year despite lots of hype surrounding their competitors.

When it comes to making Monday Night Football picks against the spread, our biggest factor was the offensive line of the Jets. Aaron Rodgers is nearly 40 years old and there are questions about how much he has left. If his offensive line can’t keep him protected, it won’t be surprising to see him display major frustrations.

This game really could go either way as the Jets defense is one of the best in the league. However, there are too many uncertainties about the Jets to feel confident picking them. If you’re going to tail any Monday Night Football predictions, it should be this one. Go with the Bills -2.5 points and take the money line (-135) at DraftKings as well.

When making our Monday Night Football picks against the spread, there really was a razor-thin margin between these two teams. On paper, both have nasty defenses and talented offenses. The difference between them is that the Bills have largely been the same group for the last 2-3 years, consistently winning together. The Jets, however, have a lot of new and important pieces to fit together. That transition might not be seamless.

The reason why our Monday Night Football picks against the spread have the Bills covering the 2.5-point spread has to do with that cohesion. Even though the Jets defense gave him fits a year ago, Bills quarterback Josh Allen finds a way to win. He did in the 20-12 victory late in 2022 against the Jets, one of the countless times he’s come up big for the Bills.

Because of the tight line, we wanted to make sure that our Monday Night Football picks against the spread were well thought out. The main difference in our pick has to do with the experience that each offense has with one another. The Jets defense is largely the same and might even be a little better thanks to the addition of Will McDonald IV.

But the Jets offense is the great unknown. Rodgers and the offense looked anything but sterling in limited preseason action. Will things get better right away against a Bills defense that has been one of the best in the league the last few years? The answer is “probably not.” Take the Bills to cover in what should be a game that goes down to the last few minutes.

How to Bet on The Bills And Win $200 Guaranteed at DraftKings

Whether you follow our Monday Night Football picks against the spread or decide to make your own Monday Night Football predictions, make sure that you use DraftKings Sportsbook. The current promotion is giving new players $200 in guaranteed bonus bets no matter what.

Simply sign up for a new account with DraftKings Sportsbook and don’t worry about a promo code. Make sure that your first deposit is at least $5 and get ready to make a wager. No matter what you pick, whether it is our Monday Night Football picks against the spread or something else, you will win $200 in bonus bets no matter what happens. There is no better way to win this weekend than with DraftKings Sportsbook.

After your first wager, which must be worth at least $5, is graded, you’ll be granted $200 in bonus bets. The bonus bets will be split into eight different bonus bet tokens which can be used at the sportsbook.

Monday Night Football Odds & Injury Report Ahead of Bills vs. Jets via DraftKings Sportsbook for Monday, September 11th, 2023

Before we could make Monday Night Football picks against the spread, we needed to know both the odds and what the injury report looked like heading into this game. The odds have the Bills as 2.5-point favorites (-110) at -135 to win outright. The Jets, +114 to win, are going to provide tough competition, especially at home.

The biggest potential injury for the Jets is running back Breece Hall. He has a knee injury that left him limited for practice on Thursday and Friday and his status is currently unspecified. For Buffalo, safety Micah Hyde was limited on Thursday but practiced in full on Friday after tweaking his back. He should be ready to go and is an important part of our Monday Night Football predictions.

Anything can change over the course of the season. Both of these teams have Super Bowl aspirations, so staying healthy is going to be a crucial component. Regular wear and tear is to be expected and one major injury could wind up being the difference between Super Bowl aspirations and another disappointing season.

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